Rebalancing agents represent a novel therapeutic class in haemophilia, designed to restore the deficient thrombin generation that underlies bleeding. Unlike factor replacement or factor VIII mimetic therapies,...
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Joint bleeds for persons with hemophilia are characteristic and can lead to hemophilic arthropathy, primarily in the ankles, knees, and elbows. The Hemophilia Joint Health Score (HJHS) is a validated physical...
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Life expectancy in people with haemophilia (PWH) has risen markedly, creating an ageing population with both age-related diseases and sequelae of historical treatment eras. Chronic hepatitis C virus (HCV)...
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Hemophilia is no longer regarded solely as a male disorder; female carriers are increasingly attracting the attention of the scientific community due to the common, albeit overlooked, bleeding tendency associated with their condition. Moreover, women can, in rare cases, experience disease severity comparable to that of hemophilic males. The overall bleeding phenotype in females is complicated by gynecological and obstetric bleedings, which do not...
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